Dissertatio epistolaris ad spectatissimum doctissimumq virum Gulielmum Cole, M.D. de observationibus nuperis circa curationem variolarum confluentium nec non de affectione hysterica
A 1682 London Latin medical dissertation by physician Thomas Sydenham, addressed to physician William Cole, on smallpox treatment and hysteria, printed for publisher Walter Kettilby. The single picture is a decorative printer's initial, a large letter S built from interlaced leafy scrollwork and fruit-like knots, with a small I beside it. A designer could take from it the dense, hand-cut vine-and-knot ornament typical of late seventeenth-century letterpress capitals, useful for historical display type or borders.
